Podosomes push through

Rho in podosomes

Integrins make a choice ignaling researchers have only a few factors with which to explain a whole lot of biology. On page 407, Goel et al. describe how two integrin variants channel the actions of a single factor, insulin-like growth factor (IGF), into two distinct pathways that induce either adhesion or proliferation. The ␤ 1A integrin variant was known to be associated with proliferation and...

Tip Based Nanomanipulation Through Successive Directional Push

Nanomanipulation refers to the process of transporting nanoscale components. It has found applications in nanodevice prototyping and biomolecular and cellular investigation. In this paper, we present an atomic force microscope (AFM) based approach for automated manipulation of nanoparticles to form designed patterns. The automated manipulation is based on a novel method, successive directional ...

Push Technology Personalization through Event Correlation

“Push Technology” stands for the ability to transfer information as a reaction to event occurrence. This demonstration proposal describes Amit, a middleware framework that resolves a major problem in this area: the gap that exists between events that are reported by various channels, and the actual cases in which the user needs to react to, hereby called; reactive situations. These situations a...

Podosomes at a glance.

Cells can contact the extracellular matrix (ECM) through a variety of specialized structures. These cell-matrix contacts contain membrane proteins such as integrins, which bind both matrix components and cellular proteins, thus bridging the substratum and the cytoskeleton (reviewed in Adams, 2001). Matrix contacts provide the physical linkage that enables cells to adhere to and migrate on (or t...

Invasive podosomes and myoblast fusion.